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Truth serum

Class of psychoactive drug

  • 8 min read
  • 3 chapters

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Through Ethanol

Although a variety of such substances have been tested, serious issues have been raised about their use scientifically, ethically, and legally. There is currently no drug proven to cause consistent or predictable enhancement of truth-telling. Subjects questioned under the influence of such substances have been found to be suggestible and their memories subject to reconstruction and fabrication. While such drugs have been used in the course of investigating civil and criminal cases, they have not been accepted by Western legal systems and legal experts as genuine investigative tools. In the United States, it has been suggested that their use is a potential violation of the Fifth Amendment of the U.S. Constitution (the right to remain silent). Concerns have also been raised through the European Court of Human Rights, arguing that use of a truth serum could be considered a violation of a human right to be free from degrading treatment, or could be considered a form of torture, and has been noted as a violation of the Inter-American Convention to Prevent and Punish Torture.

"Truth serum" was previously used in the management of psychotic patients in the practice of psychiatry. In a therapeutic context, the controlled administration of intravenous hypnotic medications is called "narcosynthesis" or "narcoanalysis". Such application was first documented by William Bleckwenn. Reliability and suggestibility of patients are concerns, and the practice of chemically inducing an involuntary mental state is now widely considered to be a form of torture.

Active chemical substances

Sedatives or hypnotics that alter higher cognitive function include ethanol, scopolamine, 3-quinuclidinyl benzilate, potent short or intermediate acting hypnotic benzodiazepines such as midazolam, flunitrazepam, and various short and ultra-short acting barbiturates, including sodium thiopental (commonly known by the brand name Pentothal) and amobarbital (formerly known as sodium amytal).

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