Vasomotor center
Portion of the medulla oblongata
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Through Carbon dioxide, Neuron and Brainstem
Structure
The vasomotor center is a collection of integrating neurons in the medulla oblongata of the middle brain stem. The term "vasomotor center" is not truly accurate, since this function relies not on a single brain structure ("center") but rather represents a network of interacting neurons.
Afferent fibres
The vasomotor center integrates nerve impulses from many places via the solitary nucleus:
- central chemoreceptors
- aortic body chemoreceptors, which send impulses via the vagus nerves
- carotid body chemoreceptors, which send impulses via the glossopharyngeal nerves
- aortic arch and brachiocephalic artery high-pressure baroreceptors, which send impulses via the aortic nerve
- carotid sinus high-pressure baroreceptors, which send impulses via the glossopharyngeal nerves
Efferent fibres
The vasomotor center gives off sympathetic fibres through the spinal cord and sympathetic ganglia, which reach vascular smooth muscle.
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Function
The vasomotor center changes vascular smooth muscle tone. This changes local and systemic blood pressure.
A drop in blood pressure leads to increased sympathetic tone from the vasomotor center. This acts to raise blood pressure.
Clinical significance
Methyldopa acts on the vasomotor center, leading to selective stimulation of α2-adrenergic receptor. Guanfacine also causes the same stimulation. This reduces sympathetic tone to vascular smooth muscle. This reduces heart rate and vascular resistance.
Digoxin increases vagal tone from the vasomotor centre, which decreases pulse.
G-series nerve agents have their most potent effect in the vasomotor center. Unlike other parts of the body, where continued stimulation of acetylcholine receptors leads to recoverable paralysis, overstimulation of the vasomotor center is often causes a fatal rise in blood pressure.
History
The localization of vasomotor center was determined by Filipp Ovsyannikov in 1871.