ADAMTS · Lablypedia

In a nutshell

ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13.

Related on Lably

Through Enzyme and Coagulation

LabLife Processes LabFrom Tasting to Digesting Lab · Class 11–12Biomolecules of Life Lab · Class 11Biomolecules — Animated Chapter Film

Like ADAMs, the name of the ADAMTS family refers to its disintegrin and metalloproteinase activity, and in the case of ADAMTS, the presence of a thrombospondin motif.

ADAMTS family members

ADAMTS1 (or METH-1), an antiangiogenic
ADAMTS2
ADAMTS3
ADAMTS4
ADAMTS5 (=ADAMTS11)
ADAMTS6
ADAMTS7
ADAMTS8 (or METH-2), an antiangiogenic
ADAMTS9
ADAMTS10
ADAMTS12
ADAMTS13
ADAMTS14
ADAMTS15
ADAMTS16
ADAMTS17
ADAMTS18
ADAMTS19
ADAMTS20

More in Human body

Anatomical terms of locationStandard terms for unambiguous description of relative placement of body parts Prefrontal cortexPart of the brain responsible for personality, decision-making, and social behavior PubMedOnline biomedical database Mucous membraneProtective layer that lines the interior of hollow organs NeuroimagingSet of techniques to measure and visualize aspects of the nervous system NeuroscientistIndividual who studies neuroscience