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Through River, Tributary and Drainage basin

The river became a primary transportation route for pioneers during the westward expansion of the early U.S. The lower Ohio River just below Louisville was obstructed by rapids known as the Falls of the Ohio where the elevation falls 26 feet (7.9 m) in 2 miles (3.2 km) restricting larger commercial navigation, although in the 18th and early 19th century its three deepest channels could be traversed by a wide variety of craft then in use. In 1830, the Louisville and Portland Canal (now the McAlpine Locks and Dam) bypassed the rapids, allowing even larger commercial and modern navigation from the Forks of the Ohio at Pittsburgh to the Port of New Orleans at the mouth of the Mississippi on the Gulf of Mexico. Since the "canalization" of the river in 1929, the Ohio has not been a natural free-flowing river; today, it is divided into 21 discrete pools or reservoirs by 20 locks and dams for navigation and power generation.

The name "Ohio" comes from the Seneca word Ohi:yo', meaning "good river". In his Notes on the State of Virginia published in 1781–82, Thomas Jefferson stated: "The Ohio is the most beautiful river on earth. Its current gentle, waters clear, and bosom smooth and unbroken by rocks and rapids, a single instance only excepted."

After the French and Indian War, Britain's trans-Appalachian Indian Reserve was divided by the river into colonial lands to the south and Native American lands to the north, but later becoming part of the British Province of Quebec. During the American Revolution in 1778, militia crossed the river to take it from the British. In the late 18th century, the river became the southern boundary of the U.S. Northwest Territory. The river was in the early 19th century considered the western extension of the Mason–Dixon line that divided Pennsylvania from Maryland, and thus part of the border between free and slave territory, and between the Northern and Southern United States or Upland South. Where the river was narrow, it was crossed by thousands of slaves escaping to the North for freedom; many were helped by free blacks and whites of the Underground Railroad resistance movement.

The Ohio River is a climatic transition area, as its water runs along the periphery of the humid continental and humid subtropical climate areas. It is inhabited by fauna and flora of both climates. During winter, it regularly freezes over in Pittsburgh but rarely farther south towards Cincinnati and Louisville. Further down the river in places like Owensboro and Paducah, closer to its confluence with the Mississippi, the Ohio is ice-free year-round.

Today, the Ohio River is one of the most polluted rivers in the United States. The Ohio has faced significant industrial pollution historically along with farm runoff.

Etymology

The name "Ohio" derives from the Seneca word Ohi:yo' (roughly pronounced oh-HEE-yoh, with the vowel in "hee" held longer), a proper name derived from ohiːyoːh ("good river"). "Great river" and "large creek" have also been given as translations.

Native Americans, including the Lenape and Haudenosaunee, considered the Ohio and Allegheny rivers as the same, as is suggested by a New York State road sign on Interstate 86 that refers to the Allegheny River also as Ohi:yo'. Similarly, the Geographic Names Information System lists O-hee-yo and O-hi-o as variant names for the Allegheny.

An earlier Miami-Illinois language name was also applied to the Ohio River, Mosopeleacipi ("river of the Mosopelea" tribe). Shortened in the Shawnee language to pelewa thiipi, spelewathiipi or peleewa thiipiiki, the name evolved through variant forms such as "Polesipi", "Peleson", "Pele Sipi" and "Pere Sipi", and eventually stabilized to the variant spellings "Pelisipi", "Pelisippi" and "Pellissippi". Originally applied just to the Ohio River, the "Pelisipi" name later was variously applied back and forth between the Ohio River and the Clinch River in Virginia and Tennessee. In his original draft of the Land Ordinance of 1784, Thomas Jefferson proposed a new state called "Pelisipia", to the south of the Ohio River, which would have included parts of present-day Eastern Kentucky, Virginia and West Virginia.

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