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Sneeze

Semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth

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A man mid-sneeze. Original CDC caption: "This 2009 photograph captured a sneeze in progress, revealing the plume of salivary droplets as they are expelled in a large cone-shaped array from this man’s
James Gathany · Public domain

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Through Lung, Brainstem and Allergy

The function of sneezing is to expel mucus containing foreign particles or irritants and cleanse the nasal cavity. During a sneeze, the soft palate and palatine uvula depress while the back of the tongue elevates to partially close the passage to the mouth, creating a venturi (similar to a carburetor) due to Bernoulli's principle so that air ejected from the lungs is accelerated through the mouth and thus creating a low pressure point at the back of the nose. This way air is forced in through the front of the nose and the expelled mucus and contaminants are launched out the mouth. Sneezing with the mouth closed does expel mucus through the nose but is not recommended because it creates a very high pressure in the head and is potentially harmful.

Description

The sneeze reflex is a two-part process involving afferent and efferent neural pathways. The afferent pathway is the sensory phase, where stimulation of specialized sensory neurons called pruriceptors in the respiratory mucosa of the nasopharynx or paranasal sinuses by chemical or mechanical irritants produces signals which are transmitted via the trigeminal nerve to the brainstem. The efferent pathway is the motor phase, where the medulla oblongata sends signals via motor nerves to several different muscle groups throughout the body to cause the forceful expulsion of air, in an effort to eliminate the offending agent.

The neural regions involved in the sneeze reflex are located in the brainstem along the ventromedial part of the spinal trigeminal nucleus and the adjacent lateral reticular formation. This region appears to control the pharyngeal, laryngeal, respiratory, and abdominal muscles; the combined activity of these muscles serves as the motor phase of a sneeze.

The motor phase of the sneeze reflex consists of an inhalation and an exhalation phase. During the inhalation phase, the diaphragm and intercostal muscles contract to draw a large volume of air into the lungs. This is followed by an expiration phase, when the muscles of the abdomen and chest contract powerfully to compress the lungs, forcing air out in a forceful burst. The muscles of the eyelids also contract involuntarily during this phase, reflexively closing the eyes. However, the common suggestion that it is impossible to sneeze with one's eyes open is inaccurate. The reflex is suppressible.

Sneezing cannot occur during sleep due to REM atonia – a bodily state where motor neurons are not stimulated and reflex signals are not relayed to the brain. Sufficient external stimulants, however, may cause a person to wake from sleep to sneeze, but any sneezing occurring afterwards would take place with a partially awake status at minimum.

Other than irritating foreign particles, allergies or possible illness, another stimulus is sudden exposure to bright light – a condition known as photic sneeze reflex (PSR). Walking out of a dark building into sunshine may trigger PSR, or the ACHOO (autosomal dominant compulsive helio-ophthalmic outbursts of sneezing) syndrome as it is also called. The tendency to sneeze upon exposure to bright light is an autosomal dominant trait and affects 18–35% of the human population. A rarer trigger, observed in some individuals, is the fullness of the stomach immediately after a large meal. This is known as snatiation and is regarded as a medical disorder passed along genetically as an autosomal dominant trait.

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