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Addictive behavior

Rewarding and reinforcing behaviours

  • 10 min read
  • 5 chapters

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Through Reinforcement, Decision-making and Compulsive behavior

Defining addictive behavior presents a challenge, as the concept encompasses diverse behaviors, and therefore its usage has been contentious. Although, central to the definition is excessive dependence on a specific substance or activity, derived from the Latin term 'to enslave.' Furthermore, addictive behavior describes patterns characterized by a loss of control and a compulsion to accept a reward despite severe consequences. This often manifests in compulsive engagement, prioritizing short-term gratification over long-term consequences, and a transition from impulsivity to compulsivity. Consequently, addictive behaviors create a spectrum of activities that entrap individuals in repetitive patterns, despite the adverse consequences, echoing the enslavement inherent in the notion of addiction.

Developments in research continue to reshape the human's understanding of addiction. Traditionally, addiction was largely associated with substance-use disorders, including alcohol and heroin, and therefore "non-substance-related (behavioral) addiction" was not listed in the two internationally used diagnostic manuals for mental disorders. However, contemporary research suggests that any stimulus capable of producing pleasure can lead to addiction. This shift broadens the scope of addiction to include excessive shopping, internet usage, computer gaming, gambling, and sex. Addictive behaviors, whether substance-related or behavioral, often involve deficiencies in inhibitory control, emotion regulation, and decision-making. There are significant overlaps in diagnostic symptoms between substance use and behavioral addiction, including dominance over one's life, euphoric experiences, withdrawal symptoms, interpersonal conflicts, and the risk of relapse despite negative outcomes.

From a neurobiological perspective, behavioral addiction may affect brain neurotransmitter systems similarly to pharmacological substances, such as the dopamine system. These behaviors often follow a three-step cycle consisting of preoccupation (anticipation), binge intoxication, and withdrawal effect, with reinforcement playing a central role in each stage. Reinforcement occurs through positive experiences during the initial engagement, negative reinforcement to alleviate withdrawal symptoms, and conditioned reinforcement where cues associated with behavior or drugs trigger intense cravings, perpetuating the addiction.

Addiction is classified as a chronic brain disorder by the American Society of Addiction Medicine (ASAM). There are several reasons why people develop an addiction. A predisposition to the addictive qualities of substances may be inherited by some people, making it a genetic circumstance. Another cause for addictions could be the environment. Whether or not someone develops substance use problems can be influenced by their home and neighborhood, as well as the attitudes of their peers, family, and culture on substance use. Another cause of developing an addiction could be related to mental health issues: over 50% of individuals with substance use disorders have experienced mental health issues at some point in their lives. Even moderate substance usage might exacerbate mental health issues in individuals. The other view is from the moral standpoint which regards addictive behavior as an intentional choice was freely made by the addict.

How addiction affects the brain

Brain imaging techniques have assisted in mapping neural circuits involved in addictive behaviors, such as reward responses, cravings, cue conditioning, and withdrawal symptoms. This has provided key insights on the underlying mechanisms of addiction, including substance use and non-substance (behavioral) addictions.

Addiction hijacks the brain's reward system, which normally encourages individuals to engage in survival-related activities such as socializing, eating, or achieving goals. Substances or specific behavioral activities create an intense "high" by flooding the reward system with dopamine, a chemical commonly known as "a feel-good chemical". Over time, the brain adapts to this surge by dampening its dopamine production and sensitivity to rewards. Consequently, the addicted individual may experience feelings of sluggishness and lack of motivation unless they consume the substance or engage in an activity to attain a sense of normalcy. This cycle of intense pleasure is followed by withdrawal symptoms and cravings, which fuel addiction.

Despite the traditional distinction between substance-use addictions and behavioral addictions, research reveals noteworthy similarities in their neurochemical mechanisms. Brain imaging studies demonstrates that both types of addiction activate similar regions in the mesolimbic reward pathway, a network linked to motivation and pleasure. Moreover, both involve changes in neurotransmitters, such as dopamine and serotonin, which are responsible for regulating mood, impulse control and reward processing. These convergent neurochemical features suggest that substance dependence and non-substance addictions follow similar fundamental stages.

The key stages of addiction are as follows:

Intoxication: Addictive substances induce dopamine surges in the mesolimbic reward system during intoxication, reinforcing a pleasurable high and establishing associations between drug-related cues and the anticipation of rewards

Adaptation: Individuals with addiction exhibit reduced dopamine production, leading to diminished sensitivity with repeated use. Besides dopamine, other neurotransmitters, such as serotonin and opioids, contribute to initial pleasurable effects (euphoria) and are also impacted by the brain's adaptation to repeated use.

Withdrawal: Upon cessation of the behavior or the drug effect wearing off, individuals experience negative mood states, including anxiety and anhedonia, due to the dampened reward system. Withdrawal processes are mediated by basal forebrain areas and neurotransmitters such as corticotropin-releasing factor (CRF) and norepinephrine.

Cravings: Conditioned cues (sight, smell, and emotions) drive cravings, prompting individuals to seek a re-experience of euphoria. Prefrontal circuits involved in highlighting the substance or addictive behavior's importance are activated, while the limbic region triggers an automatic response encouraging the pursuit of the activity or substance. Dusyfuntioning in prefrontal cortical regions impairs executive functions, making it difficult to resist craving despite adverse consequences.

These overlapping neurochemical features support the growing understanding of addiction as a border phenomenon, impacting substance-use and behavioral addictions.

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