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The Kushans were most probably one of five branches of the Yuezhi confederation, an Indo-European nomadic people of possible Tocharian origin, who migrated from northwestern China (Xinjiang and Gansu) and settled in ancient Bactria. The founder of the dynasty, Kujula Kadphises, followed Iranian and Greek cultural ideas and iconography after the Greco-Bactrian tradition. Kujula was also a follower of the Shaivite sect of Hinduism, as were two later Kushan kings Vima Kadphises and Vasudeva II. The Kushans in general were also great patrons of Buddhism, and, starting with emperor Kanishka, they employed elements of Zoroastrianism in their pantheon. They played an important role in the spread of Buddhism to Central Asia and China, ushering in a period of relative peace for 200 years, sometimes described as "Pax Kushana".

The Kushans initially used the Greek language for administrative purposes but soon began to use the Eastern Iranian Bactrian language. Kanishka sent his armies north of the Karakoram mountains. A direct road from Gandhara to China remained under Kushan control for more than a century, encouraged travel across the Karakoram, and facilitated the spread of Mahayana Buddhism to China. The Kushan dynasty had diplomatic contacts with the Roman Empire, Sasanian Persia, the Aksumite Empire, and the Han dynasty of China. It was at the center of trade relations between the Roman Empire and China: according to Alain Daniélou, "for a time, the Kushana Empire was the centerpoint of the major civilizations". While much philosophy, art, and science was created within its borders, the only textual record of the empire's history today comes from inscriptions and accounts in other languages, particularly Chinese.

The Kushan Empire fragmented into semi-independent kingdoms in the 3rd century AD, which fell to the Sasanians invading from the west and establishing the Kushano-Sasanian Kingdom in the areas of Sogdiana, Bactria, and Gandhara. In the 4th century, the Guptas, another Indian dynasty, also pressed from the east. The last of the Kushan and Kushano-Sasanian kingdoms were eventually overwhelmed by invaders from the north, known as the Kidarites, and later the Hephthalites.

Origins

Chinese sources describe the Guìshuāng (貴霜, Old Chinese: *kuj-s [s]raŋ), i.e. the Kushans, as one of the five aristocratic tribes of the Yuezhi. Many scholars believe that the Yuezhi were a people of Indo-European origin. A number of scholars have suggested a specifically Tocharian origin of the Yuezhi. An Iranic Saka origin has also been suggested by some scholars.

The Yuezhi were described in the Records of the Great Historian and the Book of Han as living in the grasslands of eastern Xinjiang and northwestern part of Gansu, in the northwest of modern-day China, until their King was beheaded by the Xiongnu (匈奴) who were also at war with China, which eventually forced them to migrate west in 176–160 BC. The five tribes constituting the Yuezhi are known in Chinese history as Xiūmì (休密), Guìshuāng (貴霜), Shuāngmǐ (雙靡), Xìdùn (肸頓), and Dūmì (都密).

The Yuezhi reached the Hellenic kingdom of Greco-Bactria (in northern Afghanistan and Uzbekistan) around 135 BC. Under the pressure of Yuezhi and the Scythians who were in turn displaced by them, the Greek dynasties moved further southeast in areas of the Hindu Kush (in present-day Afghanistan and Pakistan) and the Indus basin (in present-day Pakistan and India), where the Indo-Greek kingdoms were located.

In South Asia, Kushan emperors regularly used the dynastic name ΚΟϷΑΝΟ ("Koshano") on their coinage. Several inscriptions in Sanskrit in the Brahmi script, such as the Mathura inscription of the statue of Vima Kadphises, refer to the Kushan Emperor as , Ku-ṣā-ṇa ("Kushana"). Some later Indian literary sources referred to the Kushans as Turushka, a name which in later Sanskrit sources was confused with Turk, "probably due to the fact that Tukharistan passed into the hands of the western Turks in the seventh century". According to John M. Rosenfield, Turushka, Tukhāra or Tukhāra are variations of the word Tokhari in Indian writings. Yet, according to André Wink, "nowadays no historian considers them to be Turkish-Mongoloid or "Hun", although there is no doubt about their Central-Asian origin."

In a 2013 study for genetic analysis of the burial sites identified as belonging to Yuezhi compared with those identified as belonging to Tocharians, Lanhai et al. suggested that both were different peoples. According to the authors, the Tocharians' paternal lineages were from East Eurasians, which differed from the Yuezhi, and hence did not share the same origin. Lanhai et al. suggested the Yuezhis to be a unique Central Asian group with West Eurasian origin, dissimilar to the origins of the Tocharians. Lanhai et al. noted that more evidence was needed to resolve the Tocharian-Yuezhi relationship.

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